Ingredient Safety Standards

H&S Global upholds a high level of responsibility for consumer health and consistently adheres to the principle of ‘safety before efficacy.’ We control every ingredient from the source to ensure that all ingredients used in our products are selected based on scientific, safety, and compliance considerations.
Safety

  • 01
    Batch differences of raw materials
    We pay special attention to batch differences in raw materials and establish a dynamic safety database. For example, we monitor seasonal fluctuations in indicators such as heavy metals and pesticide residues in natural plant raw materials.
  • 02
    Adverse reaction early warning system
    Adverse reaction early warning system: Develop an AI-driven signal detection system to real-time capture adverse event reports from global regulatory authorities (e.g., the FDA FAERS database);
  • 03
    Evaluate special populations
    Utilise population pharmacokinetic models to assess the safety of use for special populations (e.g., children, pregnant women);
  • 04
    Compliance early warning database
    Establish a raw material compliance early warning database, such as a real-time update mechanism for banned ingredients in Chinese health supplements and restricted/banned ingredients in EU personal care products;
  • 05
    Quantitative management system
    Establish a ‘margin of safety (MOS)’ quantification management system to set precise safety thresholds for each product through ratio analysis of clinical and toxicological data;
  • 06
    Compliance review and security assessment
    All ingredients must undergo systematic regulatory compliance reviews and safety assessments before being included in product formulations, and their applicability across different populations, age groups, and product categories must be comprehensively considered
Scientific Basis

We adhere to a data-driven approach, ensuring that all selected active ingredients are supported by robust scientific evidence, including authoritative research literature and internationally recognised regulatory approval records, to guarantee the credibility of their efficacy. 


Develop an AI-driven literature credibility assessment matrix to screen studies across four dimensions: study quality, data consistency, mechanism clarity, and clinical relevance, to ensure the scientific validity of ingredients and formulations.
Compliance

All ingredients must comply with relevant legal and regulatory requirements and must not contain any prohibited or restricted substances. H&S Global strictly controls the scope of ingredient use and additive quantities to ensure consistency between label claims, functional positioning, and legal definitions.

Dimension A:

Geographical compliance (differences in regulations across regions such as China, the EU, and North America)

Dimension B:

Product category (different limits for health supplements, food, and personal care products)

Dimension C:

Timeline (monitoring regulatory updates, such as the EU CLP Regulation update)

Effective ingredients

We strictly evaluate the effectiveness of the ingredients based on scientific evidence, among which human clinical trials are the gold standard for verifying efficacy. Conclusions drawn from medium to large-scale randomized controlled trials (with 100 participants and a duration of more than two months) are the most convincing. When multiple independent studies yield mutually corroborating results, the efficacy of this component will be more fully confirmed. During the research and development process, we not only focus on clinical data, but also refer to the research results of cell experiments and animal experiments. These previous studies can help us gain a deeper understanding of the mechanism of action of the components and provide an important basis for subsequent clinical validation. We always maintain a rigorous scientific attitude to ensure that the efficacy of each ingredient has been fully verified.
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